For US Health Care Professionals Only
EFFICACY IN ADULTS
Proven ARR efficacy vs Avonex® and vs placebo1-3
Primary End Point
  • vs Avonex®
  • vs Placebo
TRANSFORMS Clinical Trial (Trial Assessing Injectable Interferon vs FTY720 Oral in Relapsing-Remitting Multiple Sclerosis)
In a 1-year, active-controlled study in adult patients with RRMS, GILENYA showed a
GILENYA showed a 52% relative reduction in Annualized Relapse Rate (ARR) vs Avonex GILENYA showed a 52% relative reduction in Annualized Relapse Rate (ARR) vs Avonex
More adult patients kept free of relapses3

83% free of relapses with GILENYA (n=429) vs 70% with Avonex (n=431) (P<0.001)*

*Secondary end point.

FREEDOMS Clinical Trial (FTY720 Research Evaluating Effects of Daily Oral Therapy in Multiple Sclerosis)
In a 2-year, placebo-controlled study in adult patients with RRMS, GILENYA showed a
GILENYA showed a 54% relative reduction in Annualized Relapse Rate (ARR) vs placebo GILENYA showed a 54% relative reduction in Annualized Relapse Rate (ARR) vs placebo
More adult patients kept free of relapses2
70% free of relapses with GILENYA (n=425) vs 46% with placebo (n=418) ( P<0.001)*

*Secondary end point.

Study Designs
 
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